Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites
نویسندگان
چکیده
منابع مشابه
Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.
Nitrogen-containing bisphosphonates, drugs used to treat bone resorption diseases, also have activity against a broad range of protists, including blood-stage Plasmodium spp. Here, we show that new-generation "lipophilic" bisphosphonates designed as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages, with a high (>100) therapeutic index. T...
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ژورنال
عنوان ژورنال: Cell Chemical Biology
سال: 2019
ISSN: 2451-9456
DOI: 10.1016/j.chembiol.2018.11.003